This new title covers all of the pathological conditions that are likely to be encountered in daily practice such as anaemias, bleeding and coagulation disorders, leukaemias and incorporates the latest knowledge on the molecular basis of inherited red cell and coagulation disorders.
The book is generously illustrated with high quality colours images depicted throughout. For ease of use, each chapter has been organised into a consistent format, giving details of incidence/epidemiology, pathogenesis, brief clinical presentation, histological and cytological appearance, testing techniques and diagnosis. There is also a section on clinical behaviour and possible outcomes.
Contents:
Section 1: Normal blood and bone marrow cells and hematopoiesis Normal blood cells * Normal bone marrow cells: Development, cytology and ultrastructure * Normal bone marrow: histology, histochemistry and immunohistochemistry * Regulation of hematopoiesis Section 2: Pathology of the marrow General considerations Section 3: Disorders affecting erythroid cells Investigation and classification of anaemia * Abnormalities of the red cell membrane * Inherited abnormalities of red cell enzymes * Abnormalities of the structure and synthesis of haemoglobin * Acquired haemolytic anaemias * Iron deficiency anaemia, anaemia of chronic disorder and iron overload * Macrocytic anaemia * Aplastic anaemia * Sideroblastic anaemias * Congenital dyserythropoietic anaemias * Polycythaemia (the erythrocytoses) Section 4: Disorders affecting leucocyte lineages Abnormalities in leucocyte morphology and number * Disorders of phagocyte function * Myelodysplastic disorders * Acute leukaemias * The chronic lymphoid and myeloid leukaemias and systemic mastocytosis * Lymphoma * Abnormalities in immunoglobulin synthesising cells Section 5: Abnormalities of hemostasis Hemostatis: Principles of investigation * Disorders affecting megakaryocytes and platelets: inherited conditions * Acquired disorders affecting megakaryocytes and platelets * Inherited disorders of coagulation * Acquired bleeding disorders * Natural anticoagulants and thrombophilia Section 6: Immunohematology
Blood groups on red cells, platelets and neutrophils * Transfusion medicine for the pathologist * Histocompatibility: HLA and other systems